Understanding the Difference: IM Ketamine vs. Spravato® for Depression Treatment
At Inner Journey Healthcare in Missoula, MT, we offer multiple ketamine-based treatment options for individuals experiencing treatment-resistant depression, anxiety, and related mental health conditions. Two of the most effective and widely used options are intramuscular (IM) ketamine and Spravato® (esketamine). While both are transformative tools for healing, they differ in form, administration, cost, and insurance coverage.
Let’s break down the key differences to help you understand which option might be the right fit for your journey.
What is IM Ketamine?
IM ketamine refers to a single intramuscular injection of racemic ketamine administered in a safe, monitored clinical setting. It induces a altered state of consciousness, which can support emotional processing, insight, and relief from depressive symptoms. Sessions include therapeutic support in the days before and after the experience.
Onset: Rapid (within minutes)
Duration: 2 hours per session
Therapeutic Model: Often paired with integration therapy (Ketamine-Assisted Psychotherapy, or KAP)
Insurance Coverage: Partially covered – dosing sessions are self-pay but the intakes and integrations can be billed to insurance
Flexibility: Customizable dosing and timing.
What is Spravato® (Esketamine)?
Spravato® is an FDA-approved nasal spray form of esketamine (a derivative of ketamine) used to treat treatment-resistant depression (TRD). It is administered in-office under direct supervision, with patients remaining on-site for at least two hours for observation.
Onset: Gradual (noticeable after multiple sessions)
Duration: 2+ hours per visit (twice weekly initially)
Therapeutic Model: Often used alongside oral antidepressants; not typically combined with therapy during administration
Insurance Coverage: Often fully covered for eligible patients by most major insurers (including BCBS, Aetna, and Pacific Source.)
Compliance: Must meet strict eligibility criteria; including prior authorization
Which One is Right for You?
Both IM ketamine and Spravato® offer unique benefits and can be life-changing for individuals who haven’t responded to traditional antidepressants. The right choice depends on several factors, including:
Your insurance coverage
Your preference for duration and intensity of treatment
Whether you’re looking for a more therapy-integrated experience (IM ketamine) or an FDA-approved medication protocol (Spravato®)
Your medical history and eligibility for esketamine treatment
We’re Here to Help
At Inner Journey Healthcare, we provide a comprehensive evaluation to determine the most appropriate treatment for your unique needs. Whether you're curious about Spravato®, interested in ketamine-assisted psychotherapy, or just looking to explore your options, our team is here to guide you with expertise and compassion.
Ready to learn more? Reach out today to schedule a consultation.
