SPRAVATO®

Our recommended treatment protocol for major depression begins with twice-weekly sessions for the first four weeks, followed by once-weekly sessions for the next four weeks. Ongoing maintenance treatments may be scheduled as needed based on individual progress. Each treatment requires in-office monitoring by a physician for a minimum of two hours. Patients must arrange safe transportation home, as they are not permitted to drive until they have had a full night’s sleep following treatment.

SPRAVATO® (esketamine) is distinct from traditional antidepressants in the way it affects the brain. Esketamine is a form of ketamine—specifically, the S-enantiomer of racemic ketamine. It acts on the brain’s glutamate system by blocking NMDA receptors, which are involved in mood regulation and neural communication. While the exact mechanism by which SPRAVATO® improves symptoms of depression is not fully understood, its effects are believed to be similar to those of ketamine, leading to rapid changes in brain activity and mood.

At Inner Journey Healthcare, we’re committed to making each treatment session as comfortable and effective as possible. We’ve created a calming, therapeutic environment designed to support relaxation and minimize distractions or overstimulation.

During your in-office SPRAVATO® or ketamine treatment—typically lasting about two hours—our experienced clinical staff will be present to provide continuous support. This includes clear pre-treatment guidance, monitoring for safety throughout your session, and thoughtful post-treatment care instructions.

Common side effects may include elevated blood pressure, nausea, drowsiness, dizziness, fainting, anxiety, a spinning sensation, respiratory changes, or dissociation (a sense of detachment from your thoughts, feelings, surroundings, or time). These effects are usually temporary and resolve within the same day.

The SPRAVATO® treatment protocol begins with twice-weekly sessions for the first four weeks. This is followed by once-weekly sessions for another four weeks. After that, your provider will work with you to determine an individualized maintenance schedule based on your ongoing needs and response to treatment.

To begin treatment, please call our office and request a SPRAVATO® or ketamine intake appointment. Alternatively, your psychiatrist, therapist, or primary care provider can send a referral directly to us by fax at (406) 412-2872.

At Inner Journey Healthcare, we offer both SPRAVATO® (esketamine) and intramuscular (IM) ketamine as innovative treatment options for depression and other mental health conditions. While both are derived from ketamine, there are key differences:

SPRAVATO® is a nasal spray form of esketamine—the S-enantiomer of ketamine—FDA-approved for treatment-resistant depression. It must be administered in a certified clinic under medical supervision. Many insurance plans, and commercial providers, offer coverage for SPRAVATO®.

IM Ketamine involves a small injection of the full ketamine molecule, offering a broader therapeutic effect. While not FDA-approved specifically for depression, it is widely used off-label with strong clinical support. IM ketamine may be a more cost-effective option, especially for patients without pharmacy coverage for SPRAVATO®.

Your provider will work with you to determine the most appropriate treatment based on your symptoms, goals, and insurance coverage. WE are currently accepting BCBS and Pacific Source.